
Life can be busy, and it’s easy to dismiss physical or emotional changes as just part of the daily grind. But sometimes, persistent symptoms are your body’s way of signaling that something more serious may be going on. Whether it’s due to stress, chronic illness, or a more serious condition like cancer or multiple myeloma, recognizing the signs early can make a big difference. The following are ten signs to watch out for, particularly if they persist.

1. Persistent Fatigue That Isn’t Relieved by Rest
We all feel tired from time to time. But if you’re extremely tired for weeks or months—even with lots of sleep and rest—it may be more than just stress or a hectic schedule. Illnesses such as chronic fatigue syndrome (ME/CFS), some types of cancer, or blood disorders such as multiple myeloma can all contribute to this type of debilitating fatigue. If your level of energy remains low regardless of what you do, it’s time to dig deeper.

2. Unexplained Aches and Pains
Pain or stiffness in the muscles or joints can be from normal strain or injury—still, persistent, unexplained pain is worthy of notice. ME/CFS is also known to cause continuous pain without explanation.Pain in the bones, particularly in the back or hips, may be an early sign of multiple myeloma too. If pain doesn’t get better, becomes worse, or appears with no reason, consult your healthcare provider.

3. Frequent Dizziness or Weakness
Mild lightheadedness now and then is to be expected, but if weakness or dizziness occurs frequently—particularly on standing up—it could be more than stress or dehydration. These symptoms can be caused by such conditions as anemia (frequent in multiple myeloma or certain cancers) and blood pressure abnormalities. Do not dismiss them if they continue.

4. Frequent Headaches or Changes in Vision
Occasional headaches are usually attributed to stress, dehydration, or not getting enough sleep. But frequent headaches, increased severity, or accompanied by blurred vision can indicate something more serious, like a neurological condition or even a tumor. Don’t dismiss any sudden or worsening change in how you look or feel.

5. Difficulty Sleeping or Feeling Unrestored
Sleep problems are often linked to stress—but if you’re getting a full night’s sleep and still waking up exhausted, it might be a sign of something deeper. ME/CFS can disrupt sleep patterns significantly, and some cancers can affect hormone levels and overall restfulness. If your sleep isn’t restoring you, it’s worth discussing with a doctor.

6. Unexplained Weight Loss or Loss of Appetite
Loosing weight without any effort can sound like a perk, but it is usually an alarming sign. Unwanted weight loss or unexpected reduction in appetite might indicate digestive problems, depression, chronic disease, or cancer. Notice changes in your body’s hunger cues and weight—particularly if they occur without an obvious cause.

7. Persistent Cough or Sore Throat
A cough or sore throat that persists may be due to allergies or a minor infection—but if it persists for longer than a few weeks, it’s worth investigating. Some lung, throat, or larynx cancers can masquerade this way. If it doesn’t get better with treatment or there is no apparent cause, visit your healthcare provider.

8. Skin Changes or New Lumps
New bumps, lumps, or moles or texture changes can be easy to miss—but also may be early signs of cancer. Breast cancer, skin cancer, and lymphoma tend to present this way. ME/CFS and stress aren’t usually linked with skin change, so anything new or abnormal needs to be assessed.

9. Mood Changes or Memory Issues
“Brain fog,” forgetfulness, or being emotionally off may be attributed to stress, and in some cases it is. But ME/CFS and other illnesses can do the same to your brain and mood. If you’re having trouble focusing, remembering things, or coping with your emotions—and it’s not improving—it’s worth discussing with a professional.

10. Knowing When to Get Help
It can be hard to know if a symptom is something minor or not. Rule of thumb: if it’s new, ongoing,gettingworse, or impacting your life—get it checked out. Particularly if it happens along with other red flags such as bleeding, weakness, or unexplained pain. Listen to your gut, and don’t wait until things get to that point.